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Life cycles of successful genes

 

150 human genes clustered along the horizontal axis according to their pattern of occurrence in the literature. Red areas indicate a peak in a gene's lifecycle, black represents periods where a gene is not mentioned. Download data.

Characteristic life cycles of the genes CD4, p53, IL2, IL3, GM2A. Annual frequencies of all genes were standardised to the year 2000 to account for the constant overall increase of articles per year.

More about the UniPub database.

Distribution of what we know about genes. The x-axis represents the number (n) of articles per gene ("information per gene"). The probability P(n) to find n articles about a given gene is plotted on the y-axis and decays as a power law, appearing as a straight line on a log-log plot.

Lack of correlation between the degree of interaction of proteins and their frequency in the scientific literature. To ensure a high level of accuracy, protein interactions were only included if confirmed independently by at least two experimental methods: Y2H, TAP, HMS-PCI, taken from Mering et. al. The length of time that genes are known to the scientific community (different colours) influences the correlation positively. Download data.

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