Gene Ranker: TCGA GBM 6000

Gene Details: TP53

Gene Information:
  • Entrez Gene ID: 7157
  • Gene Name: tumor protein p53
  • Synonyms: FLJ92943|LFS1|TRP53|p53
  • MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter
  • Score: 15.750
  • Rank: 4 (of 7658)
  • red = low ranking gene
  • green = high ranking gene

TP53 has been identified in a total of 18 gene list(s). Details are below.

Line of Evidence Score Comments
BACKGROUND: Broad 2000 Cancer Gene List
 1.000 --
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples
 1.000 0.472295515
BACKGROUND: NCI Cancer Genes - lung
 0.250 --
BACKGROUND: NCI Cancer Genes - ovarian
 1.000 --
BACKGROUND: Ovarian cancer candidate genes
 1.000 Repair
BACKGROUND: Review Paper by Volgestein and Kinzler
 1.000 --
BACKGROUND: Sanger Gene Census
 1.000 breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types
PATHWAYS: Expert lists
 1.000 --
PATHWAYS: Extension of core GBM pathways
 1.000 --
PATHWAYS: GBM pathways
 1.000 --
PATHWAYS: Network Analysis: >= 4 altered neighbors
 1.000 Network analysis indicates that TP53 is functionally connected to 10 altered genes: BRCA2 CDKN2A EP300 ING4 KLF6 MDM2 MDM4 PRKDC PTEN RB1.
RECENT STUDY: Hopkins Breast/colorectal cancer
 1.000 --
RECENT STUDY: Hopkins GBM
 1.000 --
RECENT STUDY: Hopkins Pancreatic cancer
 1.000 --
RECENT STUDY: TSP Lung adenocarcinoma
 1.000 --
TCGA GENE EXPRESSION: Invasion-associated
 0.500 --
TCGA RESEQUENCE: 2 or more mutations
 0.750 57 mutations found in phases I or II
TCGA SEQUENCED: GBM phase 1
 0.250 --
Total Score: 15.750

Gene does not appear in any of these lists:

BACKGROUND: Genes in fragile sites
BACKGROUND: Review Paper by Hahn and Weinberg
PATHWAYS: Cancer-associated pathways, 1 mutation
PATHWAYS: Cancer-associated pathways, >=2 mutations
PATHWAYS: Hippo pathway
PATHWAYS: KEGG COSMIC intersection
PATHWAYS: KEGG metabolic pathways
PATHWAYS: Network Analysis: 2,3 altered neighbors
PATHWAYS: Network Analysis: Sven Nelander
PATHWAYS: P53 Network
PATHWAYS: Wnt and NOTCH
TCGA COPY NUMBER: RAE Regions of Interest
TCGA GENE EXPRESSION: Alternatively spliced genes (tumor vs normal)
TCGA GENE EXPRESSION: Alternatively spliced genes associated to tumor subtype
TCGA GENE EXPRESSION: Differentially expressed between tumor and normal
TCGA GENE EXPRESSION: Subtype analysis
TCGA GENE EXPRESSION: Variably expressed
TCGA METHYLATION: Hypermethylated in GBM tumors
TCGA RESEQUENCE: 1 mutation
TCGA SEQUENCED: GBM phase 2
TCGA SEQUENCING: Exclude