Gene Ranker: TCGA GBM 6000

Gene Details: PTEN

Rank-o-Meter

Score: 16.750 Rank: 2 (of 7658) red = low ranking gene green = high ranking gene

	Line of Evidence	Score	Comments
	BACKGROUND: Broad 2000 Cancer Gene List	1.000	--
	BACKGROUND: COSMIC human mutated genes, >= 2% of all samples	1.000	0.144675036
	BACKGROUND: NCI Cancer Genes - lung	0.250	--
	BACKGROUND: NCI Cancer Genes - ovarian	1.000	--
	BACKGROUND: Ovarian cancer candidate genes	1.000	Methylation
	BACKGROUND: Review Paper by Hahn and Weinberg	1.000	--
	BACKGROUND: Review Paper by Volgestein and Kinzler	1.000	--
	BACKGROUND: Sanger Gene Census	1.000	glioma, prostate, endometrial
	PATHWAYS: Expert lists	1.000	--
	PATHWAYS: Extension of core GBM pathways	1.000	--
	PATHWAYS: GBM pathways	1.000	--
	PATHWAYS: KEGG COSMIC intersection	1.000	--
	PATHWAYS: KEGG metabolic pathways	1.000	--
	RECENT STUDY: Hopkins Breast/colorectal cancer	1.000	--
	RECENT STUDY: Hopkins GBM	1.000	--
	TCGA COPY NUMBER: RAE Regions of Interest	1.000	--
	TCGA GENE EXPRESSION: Invasion-associated	0.500	--
	TCGA RESEQUENCE: 2 or more mutations	0.750	46 mutations found in phases I or II
	TCGA SEQUENCED: GBM phase 1	0.250	--
	Total Score:	16.750

Gene does not appear in any of these lists: