Gene Ranker: TCGA GBM 6000

Gene Details: PLCG1

Gene Information:
  • Entrez Gene ID: 5335
  • Gene Name: phospholipase C, gamma 1
  • Synonyms: PLC-II|PLC1|PLC148|PLCgamma1
  • MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter
  • Score: 8.000
  • Rank: 37 (of 7658)
  • red = low ranking gene
  • green = high ranking gene

PLCG1 has been identified in a total of 9 gene list(s). Details are below.

Line of Evidence Score Comments
BACKGROUND: Broad 2000 Cancer Gene List
 1.000 --
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples
 1.000 0.028169014
PATHWAYS: Cancer-associated pathways, 1 mutation
 1.000 Pathways: ErbB|Glioma|NK Mediated Citotoxicity|Non-small cell lung cancer|Tcell receptor|VEGF
Number of mutations in the Vogelstein discovery phase: 1
Number of mutations in the Vogelstein prevalance phase: 1
PATHWAYS: GBM pathways
 1.000 --
PATHWAYS: KEGG COSMIC intersection
 1.000 --
PATHWAYS: KEGG metabolic pathways
 1.000 --
PATHWAYS: Network Analysis: >= 4 altered neighbors
 1.000 Network analysis indicates that PLCG1 is functionally connected to 7 altered genes: EGFR ERBB2 KDR KIT MET PDGFRA PIK3R1.
TCGA GENE EXPRESSION: Invasion-associated
 0.500 --
TCGA GENE EXPRESSION: Subtype analysis
 0.500 --
Total Score: 8.000

Gene does not appear in any of these lists:

BACKGROUND: Genes in fragile sites
BACKGROUND: NCI Cancer Genes - lung
BACKGROUND: NCI Cancer Genes - ovarian
BACKGROUND: Ovarian cancer candidate genes
BACKGROUND: Review Paper by Hahn and Weinberg
BACKGROUND: Review Paper by Volgestein and Kinzler
BACKGROUND: Sanger Gene Census
PATHWAYS: Cancer-associated pathways, >=2 mutations
PATHWAYS: Expert lists
PATHWAYS: Extension of core GBM pathways
PATHWAYS: Hippo pathway
PATHWAYS: Network Analysis: 2,3 altered neighbors
PATHWAYS: Network Analysis: Sven Nelander
PATHWAYS: P53 Network
PATHWAYS: Wnt and NOTCH
RECENT STUDY: Hopkins Breast/colorectal cancer
RECENT STUDY: Hopkins GBM
RECENT STUDY: Hopkins Pancreatic cancer
RECENT STUDY: TSP Lung adenocarcinoma
TCGA COPY NUMBER: RAE Regions of Interest
TCGA GENE EXPRESSION: Alternatively spliced genes (tumor vs normal)
TCGA GENE EXPRESSION: Alternatively spliced genes associated to tumor subtype
TCGA GENE EXPRESSION: Differentially expressed between tumor and normal
TCGA GENE EXPRESSION: Variably expressed
TCGA METHYLATION: Hypermethylated in GBM tumors
TCGA RESEQUENCE: 1 mutation
TCGA RESEQUENCE: 2 or more mutations
TCGA SEQUENCED: GBM phase 1
TCGA SEQUENCED: GBM phase 2
TCGA SEQUENCING: Exclude