Gene Ranker: TCGA GBM 6000

Gene Details: MLH1

Gene Information:
  • Entrez Gene ID: 4292
  • Gene Name: mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  • Synonyms: COCA2|FCC2|HNPCC|HNPCC2|MGC5172|hMLH1
  • MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter
  • Score: 8.750
  • Rank: 24 (of 7658)
  • red = low ranking gene
  • green = high ranking gene

MLH1 has been identified in a total of 11 gene list(s). Details are below.

Line of Evidence Score Comments
BACKGROUND: Broad 2000 Cancer Gene List
 1.000 --
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples
 1.000 0.037262357
BACKGROUND: NCI Cancer Genes - lung
 0.250 --
BACKGROUND: NCI Cancer Genes - ovarian
 1.000 --
BACKGROUND: Ovarian cancer candidate genes
 1.000 Repair/Methylation
BACKGROUND: Review Paper by Volgestein and Kinzler
 1.000 --
BACKGROUND: Sanger Gene Census
 1.000 colorectal, endometrial, ovarian, CNS
PATHWAYS: Extension of core GBM pathways
 1.000 --
PATHWAYS: Network Analysis: 2,3 altered neighbors
 0.500 Network analysis indicates that MLH1 is functionally connected to 2 altered genes: MSH6 ZC3H11A.
TCGA RESEQUENCE: 2 or more mutations
 0.750 2 mutations found in phases I or II
TCGA SEQUENCED: GBM phase 1
 0.250 --
Total Score: 8.750

Gene does not appear in any of these lists:

BACKGROUND: Genes in fragile sites
BACKGROUND: Review Paper by Hahn and Weinberg
PATHWAYS: Cancer-associated pathways, 1 mutation
PATHWAYS: Cancer-associated pathways, >=2 mutations
PATHWAYS: Expert lists
PATHWAYS: GBM pathways
PATHWAYS: Hippo pathway
PATHWAYS: KEGG COSMIC intersection
PATHWAYS: KEGG metabolic pathways
PATHWAYS: Network Analysis: >= 4 altered neighbors
PATHWAYS: Network Analysis: Sven Nelander
PATHWAYS: P53 Network
PATHWAYS: Wnt and NOTCH
RECENT STUDY: Hopkins Breast/colorectal cancer
RECENT STUDY: Hopkins GBM
RECENT STUDY: Hopkins Pancreatic cancer
RECENT STUDY: TSP Lung adenocarcinoma
TCGA COPY NUMBER: RAE Regions of Interest
TCGA GENE EXPRESSION: Alternatively spliced genes (tumor vs normal)
TCGA GENE EXPRESSION: Alternatively spliced genes associated to tumor subtype
TCGA GENE EXPRESSION: Differentially expressed between tumor and normal
TCGA GENE EXPRESSION: Invasion-associated
TCGA GENE EXPRESSION: Subtype analysis
TCGA GENE EXPRESSION: Variably expressed
TCGA METHYLATION: Hypermethylated in GBM tumors
TCGA RESEQUENCE: 1 mutation
TCGA SEQUENCED: GBM phase 2
TCGA SEQUENCING: Exclude