Gene Ranker: TCGA GBM 6000

Gene Details: SMAD4

Gene Information:
  • Entrez Gene ID: 4089
  • Gene Name: SMAD family member 4
  • Synonyms: DPC4|JIP|MADH4
  • MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter
  • Score: 8.750
  • Rank: 26 (of 7658)
  • red = low ranking gene
  • green = high ranking gene

SMAD4 has been identified in a total of 12 gene list(s). Details are below.

Line of Evidence Score Comments
BACKGROUND: Broad 2000 Cancer Gene List
 1.000 --
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples
 1.000 0.089829476
BACKGROUND: NCI Cancer Genes - lung
 0.250 --
BACKGROUND: NCI Cancer Genes - ovarian
 1.000 --
BACKGROUND: Review Paper by Volgestein and Kinzler
 1.000 --
BACKGROUND: Sanger Gene Census
 1.000 colorectal, pancreatic, small intestine
PATHWAYS: Network Analysis: 2,3 altered neighbors
 0.500 Network analysis indicates that SMAD4 is functionally connected to 3 altered genes: EP300 FN1 UHRF2.
RECENT STUDY: Hopkins Breast/colorectal cancer
 1.000 --
RECENT STUDY: Hopkins Pancreatic cancer
 1.000 --
TCGA GENE EXPRESSION: Invasion-associated
 0.500 --
TCGA RESEQUENCE: 1 mutation
 0.250 1 mutation found in phases I or II
TCGA SEQUENCED: GBM phase 1
 0.250 --
Total Score: 8.750

Gene does not appear in any of these lists:

BACKGROUND: Genes in fragile sites
BACKGROUND: Ovarian cancer candidate genes
BACKGROUND: Review Paper by Hahn and Weinberg
PATHWAYS: Cancer-associated pathways, 1 mutation
PATHWAYS: Cancer-associated pathways, >=2 mutations
PATHWAYS: Expert lists
PATHWAYS: Extension of core GBM pathways
PATHWAYS: GBM pathways
PATHWAYS: Hippo pathway
PATHWAYS: KEGG COSMIC intersection
PATHWAYS: KEGG metabolic pathways
PATHWAYS: Network Analysis: >= 4 altered neighbors
PATHWAYS: Network Analysis: Sven Nelander
PATHWAYS: P53 Network
PATHWAYS: Wnt and NOTCH
RECENT STUDY: Hopkins GBM
RECENT STUDY: TSP Lung adenocarcinoma
TCGA COPY NUMBER: RAE Regions of Interest
TCGA GENE EXPRESSION: Alternatively spliced genes (tumor vs normal)
TCGA GENE EXPRESSION: Alternatively spliced genes associated to tumor subtype
TCGA GENE EXPRESSION: Differentially expressed between tumor and normal
TCGA GENE EXPRESSION: Subtype analysis
TCGA GENE EXPRESSION: Variably expressed
TCGA METHYLATION: Hypermethylated in GBM tumors
TCGA RESEQUENCE: 2 or more mutations
TCGA SEQUENCED: GBM phase 2
TCGA SEQUENCING: Exclude