Gene Ranker: TCGA GBM 6000

Gene Details: EGFR

Gene Information:

Entrez Gene ID: 1956
Gene Name: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Synonyms: ERBB|ERBB1|HER1|PIG61|mENA
MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter

EGFR has been identified in a total of 19 gene list(s). Details are below.

Line of Evidence	Score	Comments
BACKGROUND: Broad 2000 Cancer Gene List	1.000	--
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples	1.000	0.178609163
BACKGROUND: NCI Cancer Genes - lung	0.250	--
BACKGROUND: NCI Cancer Genes - ovarian	1.000	--
BACKGROUND: Review Paper by Volgestein and Kinzler	1.000	--
BACKGROUND: Sanger Gene Census	1.000	glioma, NSCLC
PATHWAYS: Expert lists	1.000	--
PATHWAYS: Extension of core GBM pathways	1.000	--
PATHWAYS: GBM pathways	1.000	--
PATHWAYS: Network Analysis: >= 4 altered neighbors	1.000	Network analysis indicates that EGFR is functionally connected to 10 altered genes: ERBB2 FRS2 JAK2 MET PIK3C2B PIK3CA PIK3R1 SH3GL2 TNC TNK2.
PATHWAYS: Network Analysis: Sven Nelander	1.000	--
RECENT STUDY: Hopkins GBM	1.000	--
RECENT STUDY: TSP Lung adenocarcinoma	1.000	--
TCGA COPY NUMBER: RAE Regions of Interest	1.000	--
TCGA GENE EXPRESSION: Invasion-associated	0.500	--
TCGA GENE EXPRESSION: Subtype analysis	0.500	--
TCGA GENE EXPRESSION: Variably expressed	0.500	--
TCGA RESEQUENCE: 2 or more mutations	0.750	23 mutations found in phases I or II
TCGA SEQUENCED: GBM phase 1	0.250	--
Total Score:	15.750