Gene Ranker: TCGA GBM 6000

Gene Details: CDKN2A

Gene Information:

Entrez Gene ID: 1029
Gene Name: cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Synonyms: ARF|CDK4I|CDKN2|CMM2|INK4|INK4a|MLM|MTS1|TP16|p14|p14ARF|p16|p16INK4|p16INK4a|p19
MapBack Info [graphical summary of known mutations in COSMIC.]

Rank-o-Meter

CDKN2A has been identified in a total of 19 gene list(s). Details are below.

Line of Evidence	Score	Comments
BACKGROUND: Broad 2000 Cancer Gene List	1.000	--
BACKGROUND: COSMIC human mutated genes, >= 2% of all samples	1.000	0.158424955
BACKGROUND: NCI Cancer Genes - lung	0.250	--
BACKGROUND: NCI Cancer Genes - ovarian	1.000	--
BACKGROUND: Ovarian cancer candidate genes	1.000	Methylation
BACKGROUND: Review Paper by Hahn and Weinberg	1.000	--
BACKGROUND: Review Paper by Volgestein and Kinzler	1.000	--
BACKGROUND: Sanger Gene Census	1.000	melanoma, multiple other tumour types
PATHWAYS: Expert lists	1.000	--
PATHWAYS: Extension of core GBM pathways	1.000	--
PATHWAYS: GBM pathways	1.000	--
PATHWAYS: Network Analysis: 2,3 altered neighbors	0.500	Network analysis indicates that CDKN2A is functionally connected to 3 altered genes: CDK4 MDM2 TP53.
PATHWAYS: Network Analysis: Sven Nelander	1.000	--
RECENT STUDY: Hopkins GBM	1.000	--
RECENT STUDY: Hopkins Pancreatic cancer	1.000	--
RECENT STUDY: TSP Lung adenocarcinoma	1.000	--
TCGA COPY NUMBER: RAE Regions of Interest	1.000	--
TCGA RESEQUENCE: 2 or more mutations	0.750	2 mutations found in phases I or II
TCGA SEQUENCED: GBM phase 1	0.250	--
Total Score:	16.750