Sarcoma (MSKCC / Broad)

Sarcoma

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

The Sarcoma Genome Project is a collaboration between Memorial Sloan-Kettering Cancer Center and The Broad Institute.

Nature Genetics. 2010 July 4. [Abstract] [Full Text] [PDF] [Data via GEO] [Data Portal]

Highlights:
  • Integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes
  • Detailed map of molecular alterations across diverse sarcoma subtypes
  • PIK3CA is mutated in 18% of myxoid and round-cell liposarcomas and associated with Akt activation and poor clinical outcome
  • NF1 is mutated and deleted in myxofibrosarcomas and pleomorphic liposarcomas
  • shRNA knockdown of genes amplified in dedifferentiated liposarcoma idenifies genes involved in cell proliferation

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News

The CGDS R-package has been released.

NetBox version 1 has been released.

The Cancer Genome Atlas has announced the selection of six Genome Data Analysis Centers.

Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

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