Prostate Cancer Signaling Pathways

Prostate Cancer

Pathway alterations in prostate cancer

diagram

A map of central cancer pathways, with an emphasis on prostate cancer, was created through manual review of the literature (2008) and assembled in Cytoscape.

The full map is available in PDF and Cytoscape CYS format.

The pathways shown below are the ones with the highest apparent alteration frequencies. To determine pathway alteration frequencies, gene alterations were defined by up- or down-regulation compared to normal prostate (outlier expression), or by somatic non-synonymous mutations. A given tumor was considered altered if at least one gene in the pathway was altered. Mutations in genes known to be frequently deleted or down-regulated were considered as inactivating mutations (shades of blue in the figures), while mutations in genes known to be frequently amplified or up-regulated were considered as activating mutations (shades of red).

diagram

diagram

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Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

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