Prostate Cancer Mutations

Prostate Cancer

Functional assessment of somatic mutations in prostate cancer

Eighty tumors were examined for somatic mutations in 138 genes by exon sequencing (Sequenced genes and primers). These and an additional 76 tumors were also profiled for well-known oncogenic mutations in 22 genes by mass spectrometry using the iPLEX Sequenom assay. In total, 84 confirmed somatic mutations were detected in 57 different genes. Thirty-seven percent of the missense mutations we detected are predicted to affect protein function based on an algorithm that uses a combination of evolutionary information from protein-family sequence alignments and residue placement in known or homology-deduced three-dimensional protein and complex structures (Mutation Assessor, B. Reva et al.).

The table below lists all validated mutations and provides links to functional predictions (via Mutation Assessor):

gene mutations missense nonsense frameshift splice mutation details
AR 4 4 W742C, H875Y, T878A (2x)
EPHA2 3 3 T502I, T898M, D942N
FLT4 3 3 E350V, P641S, V1355M
NCOR2 3 1 1 1 R323fs, W615*, P1291A
PTCH1 3 3 D55H, L1024P, S1203R
PTK7 2 1 1 R269H, e7-3 splice
PTPN11 3 3 N58S, D64N, A392V
PTPRF 3 3 e22 splice, T1653K, A1841V
ABL2 2 2 S1098N (2x)
APC 2 1 1 E1577*, D1748N
AXL 2 1 1 L50F, e11-1 splice
BRCA2 2 2 R107K, T630I
EP300 2 2 G213R, M2130I
EPS15 2 2 N69S, A844V
FGFR1 2 2 T357I, P772S
IL16 2 1 1 Q165*, R319H
KIT 2 2 e7 splice, e21 splice
MEN1 2 1 1 e2 splice, R98Q
NCOA2 2 2 G435S, S1024N
NTRK1 2 2 R6W, R444Q
PIK3CA 2 2 E545K, H1047R
PTPN14 2 2 E189G, A921V
TP53 2 2 R248W, R273C
TSC2 2 2 P131H, E158K
PTPN14 1 1 E189G
ABL1 1 1 G725S
AKT2 1 1 e10+2
BLM 1 1 H281P
BRAF 1 1 V600E
BTK 1 1 V319M
CDH1 1 1 V475A
CTNNB1 1 1 W383G
EGFR 1 1 R149Q
EPHA1 1 1 D379fs
EPHB2 1 1 E687K
EPHB4 1 1 P843Q
EPHB6 1 1 V445M
ETV1 1 1 P395Q
ETV5 1 1 A177T
IDH2 1 1 R172K
IL6ST 1 1 P434R
INSR 1 1 A1050V
KRAS 1 1 G12V
MAP3K2 1 1 G359D
MSH6 1 1 V250A
MYCL1 1 1 G232C
NF1 1 1 V2511L
NRIP1 1 1 C760S
PAK6 1 1 A270T
PIK3C2B 1 1 S721L
PIK3CB 1 1 M68V
PIK3CG 1 1 T330M
PTK2B 1 1 Q359E
PTPN3 1 1 e7-4
PTPRR 1 1 S70P
SHQ1 1 1 P22S
TNK2 1 1 R988W
WAS 1 1 D283N
XPC 1 1 G734S

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Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

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