Prostate Cancer (MSKCC)

Prostate Cancer

Integrative genomic profiling of human prostate cancer

Analysis of DNA copy number, mRNA and microRNA expression, and focused exon resequencing in 218 primary and metastatic prostate cancers as well as 12 cell lines and xenografts.

Cancer Cell. 2010 Jun 24. [Abstract] [Full Text] [PDF] [Data via GEO] [Data Portal]

Highlights:

  • Integrated genomic profiling of 218 prostate tumors provides a unique public resource
  • Androgen receptor coactivator NCOA2 is amplified in primary and metastatic disease
  • TMPRSS2-ERG positive tumors associate with 3p14 loss and its candidate target genes FOXP1, RYBP, SHQ1
  • Degree and pattern of CNAs in primary tumors is associated with risk of relapse

Use the links below for detailed results on signaling pathways and mutations, and access to the genomic data. Also visit the Data Portal to explore the data.

Signaling Pathways

Signaling Pathways

Mutations

Mutations

Additional Data

Additional Data

Cancer Genomics Sidebar

Data Portal

Explore cancer genomics data via the cBio Cancer Genomics Portal.

News

The CGDS R-package has been released.

NetBox version 1 has been released.

The Cancer Genome Atlas has announced the selection of six Genome Data Analysis Centers.

Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

Gene Ranker

Explore cancer genes with Gene Ranker.