Glioblastoma Mutations

Glioblastoma

Somatic mutations in glioblastoma (TCGA)

glioblastoma 3D mutationThe following table represents mutations found in 91 glioblastoma samples. The analysis is based on 601 sequenced genes, and only genes with two or more missense mutations are shown.

Genes in the table are hyperlinked to more detailed mutation information from the cBio Cancer Genomics Portal, which also shows the predicted functional impact of missense mutations (computed by Mutation Assessor).

gene samples mutations missense nonsense frameshift splicesite
TP53 31 38 31 2 4 1
PTEN 28 30 12 6 12
NF1 13 19 5 6 4 4
EGFR 15 16 16
ERBB2 10 11 10 1
PIK3R1 9 9 3 6
PIK3CA 6 6 4 2
COL1A1 2 4 3 1
FN1 3 4 4
MSH6 4 4 4
EP300 3 3 3
FURIN 2 3 3
ITGB3 3 3 3
MLH1 2 3 3
TNC 3 3 3
TSC2 2 3 3
A2M 2 2 2
ABCC4 2 2 2
ASPM 1 2 2
BCAR1 2 2 2
AGAP2 (CENTG1) 2 2 2
CHAT 2 2 2
CYP27B1 2 2 2
EPHA7 2 2 2
GATA3 2 2 2
HSP90AA1 2 2 2
IRS1 2 2 2
LDHA 2 2 2
MAPK9 2 2 2
MSH2 2 2 2
MSI1 2 2 2
NMBR 2 2 2
NOS3 1 2 2
PDGFRB 2 2 2
PI15 2 2 2
PRKCZ 2 2 2
PTPN11 2 2 2
ROR2 2 2 2
TAF1 2 2 2
TERT 2 2 2
TRIM3 2 2 2
ZNF384 1 2 2

Cancer Genomics Sidebar

Data Portal

Explore cancer genomics data via the cBio Cancer Genomics Portal.

News

The CGDS R-package has been released.

NetBox version 1 has been released.

The Cancer Genome Atlas has announced the selection of six Genome Data Analysis Centers.

Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

Gene Ranker

Explore cancer genes with Gene Ranker.