Glioblastoma (TCGA)

Glioblastoma

Integrated analysis of genetic alterations in a large set of glioblastoma samples from The Cancer Genome Atlas (TCGA) project

The Cancer Genome Atlas Project is an NIH-sponsored program to systematically catalog the genetic alterations in human cancers. The first cancer type investigated is Glioblastoma multiforme (GBM), the most common and most aggressive form of brain cancer.

This site presents the results of detailed analysis and access to analysis tools in the areas of signaling pathways, mutations, and copy number alterations.

Some of these results are reported in the first TCGA publication: Comprehensive genomic characterization defines human glioblastoma genes and core pathways (4 September 2008, Nature). The Cancer Genome Atlas Research Network. [Abstract] [PDF] [Supplementary information].

A more detailed analysis can be found in our recent publication: Automated network analysis identifies core pathways in glioblastoma (12 February 2010, PLoS One). Cerami et al. [PubMed Abstract] [Full Text] [PDF].

Glioblastoma Pathways

Signaling Pathways

Glioblastoma Mutations

Mutations

 DNA Copy Number

DNA Copy Number

Cancer Genomics Sidebar

Data Portal

Explore cancer genomics data via the cBio Cancer Genomics Portal.

News

The CGDS R-package has been released.

NetBox version 1 has been released.

The Cancer Genome Atlas has announced the selection of six Genome Data Analysis Centers.

Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

Gene Ranker

Explore cancer genes with Gene Ranker.