Computational Biology Center Publications

A progenitor cell origin of myeloid malignancies. (2009)

Haeno H, Levine RL, Gilliland DG, Michor F

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16616-21.

Evolution of Resistance to Targeted Anti-Cancer Therapies during Continuous and Pulsed Administration Strategies. (2009)

Foo J, Michor F

PLoS Comput Biol. 2009 Nov;5(11):e1000557.

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Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib. (2009)

Foo J, Drummond MW, Clarkson B, Holyoake T, Michor F

PLoS Comput Biol. 2009 Sep;5(9):e1000503.

[PubMed Abstract]

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Evolutionary theory of cancer. (2009)

Attolini CS, Michor F

Ann N Y Acad Sci. 2009 Jun;1168:23-51.

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A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1). (2008)

Liso A, Castiglione F, Cappuccio A, Stracci F, Schlenk RF, Amadori S, Thiede C, Schnittger S, Valk PJ, D??hner K, Martelli MF, Schaich M, Krauter J, Ganser A, Martelli MP, Bolli N, L??wenberg B, Haferlach T, Ehninger G, Mandelli F, D??hner H, Michor F, Falini B

Haematologica. 2008 Jul 4;

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Mathematical models of cancer stem cells. (2008)

Michor F

J Clin Oncol. 2008 Jun 10;26(17):2854-61.

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The evolution of two mutations during clonal expansion. (2007)

Haeno H, Iwasa Y, Michor F

Genetics. 2007 Dec;177(4):2209-21.

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Chronic myeloid leukemia blast crisis arises from progenitors. (2007)

Michor F

Stem Cells. 2007 May;25(5):1114-8.

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The emergence of tumor metastases. (2007)

Dingli D, Michor F, Antal T, Pacheco JM

Cancer Biol Ther. 2007 Mar;6(3):383-90.

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(A)symmetric stem cell replication and cancer. (2007)

Dingli D, Traulsen A, Michor F

PLoS Comput Biol. 2007 Mar 16;3(3):e53.

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Quantitative approaches to analyzing imatinib-treated chronic myeloid leukemia. (2007)

Michor F

Trends Pharmacol Sci. 2007 May;28(5):197-9.

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Synergy and discounting of cooperation in social dilemmas. (2006)

Hauert C, Michor F, Nowak MA, Doebeli M

J Theor Biol. 2006 Mar 21;239(2):195-202.

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Stochastic dynamics of metastasis formation. (2006)

Michor F, Nowak MA, Iwasa Y

J Theor Biol. 2006 Jun 21;240(4):521-30.

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Genetic instability and the quasispecies model. (2006)

Brumer Y, Michor F, Shakhnovich EI

J Theor Biol. 2006 Jul 21;241(2):216-22.

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Genetic instability and clonal expansion. (2006)

Nowak MA, Michor F, Iwasa Y

J Theor Biol. 2006 Jul 7;241(1):26-32.

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Evolution of resistance to cancer therapy. (2006)

Michor F, Nowak MA, Iwasa Y

Curr Pharm Des. 2006;12(3):261-71.

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Dynamics of metastasis suppressor gene inactivation. (2006)

Michor F, Iwasa Y

J Theor Biol. 2006 Aug 7;241(3):676-89.

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Evolution of resistance during clonal expansion. (2006)

Iwasa Y, Nowak MA, Michor F

Genetics. 2006 Apr;172(4):2557-66.

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Successful therapy must eradicate cancer stem cells. (2006)

Dingli D, Michor F

Stem Cells. 2006 Dec;24(12):2603-10.

[PubMed Abstract]

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The age incidence of chronic myeloid leukemia can be explained by a one-mutation model. (2006)

Michor F, Iwasa Y, Nowak MA

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14931-4.

[PubMed Abstract]

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Mathematical models of targeted cancer therapy. (2006)

Abbott LH, Michor F

Br J Cancer. 2006 Nov 6;95(9):1136-41.

[PubMed Abstract]

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Virus evolution within patients increases pathogenicity. (2005)

Iwasa Y, Michor F, Nowak MA

J Theor Biol. 2005 Jan 7;232(1):17-26.

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Can chromosomal instability initiate tumorigenesis? (2005)

Michor F, Iwasa Y, Vogelstein B, Lengauer C, Nowak MA

Semin Cancer Biol. 2005 Feb;15(1):43-9.

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Population genetics of tumor suppressor genes. (2005)

Iwasa Y, Michor F, Komarova NL, Nowak MA

J Theor Biol. 2005 Mar 7;233(1):15-23.

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Chromosomal instability and human cancer. (2005)

Michor F

Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):631-5.

[PubMed Abstract]

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Dynamics of chronic myeloid leukaemia. (2005)

Michor F, Hughes TP, Iwasa Y, Branford S, Shah NP, Sawyers CL, Nowak MA

Nature. 2005 Jun 30;435(7046):1267-70.

[PubMed Abstract]

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Dynamics of colorectal cancer. (2005)

Michor F, Iwasa Y, Lengauer C, Nowak MA

Semin Cancer Biol. 2005 Dec;15(6):484-93.

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Evolutionary dynamics of invasion and escape. (2004)

Iwasa Y, Michor F, Nowak MA

J Theor Biol. 2004 Jan 21;226(2):205-14.

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Linear model of colon cancer initiation. (2004)

Michor F, Iwasa Y, Rajagopalan H, Lengauer C, Nowak MA

Cell Cycle. 2004 Mar;3(3):358-62.

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Dynamics of cancer progression. (2004)

Michor F, Iwasa Y, Nowak MA

Nat Rev Cancer. 2004 Mar;4(3):197-205.

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Stochastic tunnels in evolutionary dynamics. (2004)

Iwasa Y, Michor F, Nowak MA

Genetics. 2004 Mar;166(3):1571-9.

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Some basic properties of immune selection. (2004)

Iwasa Y, Michor F, Nowak M

J Theor Biol. 2004 Jul 21;229(2):179-88.

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Evolutionary dynamics of tumor suppressor gene inactivation. (2004)

Nowak MA, Michor F, Komarova NL, Iwasa Y

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10635-8.

[PubMed Abstract]

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Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response. (2004)

Jones NA, Wei X, Flower DR, Wong M, Michor F, Saag MS, Hahn BH, Nowak MA, Shaw GM, Borrow P

J Exp Med. 2004 Nov 15;200(10):1243-56.

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Local regulation of homeostasis favors chromosomal instability. (2003)

Michor F, Iwasa Y, Komarova NL, Nowak MA

Curr Biol. 2003 Apr 1;13(7):581-4.

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Stochastic elimination of cancer cells. (2003)

Michor F, Nowak MA, Frank SA, Iwasa Y

Proc Biol Sci. 2003 Oct 7;270(1528):2017-24.

[PubMed Abstract]

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Somatic selection for and against cancer. (2003)

Michor F, Frank SA, May RM, Iwasa Y, Nowak MA

J Theor Biol. 2003 Dec 7;225(3):377-82.

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The linear process of somatic evolution. (2003)

Nowak MA, Michor F, Iwasa Y

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14966-9.

[PubMed Abstract]

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Evolutionary dynamics of escape from biomedical intervention. (2003)

Iwasa Y, Michor F, Nowak MA

Proc Biol Sci. 2003 Dec 22;270(1533):2573-8.

[PubMed Abstract]

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Evolution: the good, the bad and the lonely. (2002)

Michor F, Nowak MA

Nature. 2002 Oct 17;419(6908):677, 679.

[PubMed Abstract]

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