Computational Biology Center Publications

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. (2009)

Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, Rusch V, Pao W, Gerald W, Ladanyi M

Oncogene. 2009 Jun 15;

[PubMed Abstract]

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The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. (2009)

Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, Mischel PS, Sander C, Taylor B, Schultz N, Major J, Heguy A, Fang F, Mellinghoff IK, Chan TA

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9435-40.

[PubMed Abstract]

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Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. (2009)

King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL

Nat Genet. 2009 May;41(5):524-6.

[PubMed Abstract]

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(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. (2009)

Pratilas CA, Taylor BS, Ye Q, Viale A, Sander C, Solit DB, Rosen N

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4519-24.

[PubMed Abstract]

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways. (2008)

Cancer Genome Atlas Research Network

Nature. 2008 Oct 23;455(7216):1061-8.

[PubMed Abstract]

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Genetic predictors of MEK dependence in non-small cell lung cancer. (2008)

Pratilas CA, Hanrahan AJ, Halilovic E, Persaud Y, Soh J, Chitale D, Shigematsu H, Yamamoto H, Sawai A, Janakiraman M, Taylor BS, Pao W, Toyooka S, Ladanyi M, Gazdar A, Rosen N, Solit DB

Cancer Res. 2008 Nov 15;68(22):9375-83.

[PubMed Abstract]

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Functional copy-number alterations in cancer. (2008)

Taylor BS, Barretina J, Socci ND, Decarolis P, Ladanyi M, Meyerson M, Singer S, Sander C

PLoS ONE. 2008;3(9):e3179.

[PubMed Abstract]

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Humoral response profiling reveals pathways to prostate cancer progression. (2007)

Taylor BS, Pal M, Yu J, Laxman B, Sundaram SK, Zhao R, Menon A, Wei JT, Nesvizhskii AI, Ghosh D, Omenn GS, Lubman DM, Chinnaiyan AM, Sreekumar A

Mol Cell Proteomics. 2007 Dec 11;

[PubMed Abstract]