COSMIC database files: cosmic_v28

Input protein sequence filename: TK_proteins.fa

Click on the linked protein name to see the domain multiple alignment and mutation data summary in the context of that protein.
ABL1 isoform a
(215 mutations, of which 31 are distinct)
ABL1 isoform b
(215 mutations, of which 31 are distinct)
ABL2 isoform a
(3 mutations, of which 2 are distinct)
ABL2 isoform b ALK
(5 mutations, of which 4 are distinct)
AXL isoform 1
(5 mutations, of which 3 are distinct)
AXL isoform 2
(5 mutations, of which 3 are distinct)
BLK
(1 mutation)
BMX isoform a.1
(1 mutation)
BMX isoform a.2
(1 mutation)
BRAF
(4139 mutations, of which 44 are distinct)
BTK
(2 mutations, of which 1 is distinct)
CSF1R
(41 mutations, of which 8 are distinct)
CSK
(4 mutations, of which 2 are distinct)
DDR1 isoform a
DDR1 isoform b DDR1 isoform c DDR2 isoform a.1
(2 mutations, of which 1 is distinct)
DDR2 isoform a.2
(2 mutations, of which 1 is distinct)
EGFR isoform a
(6777 mutations, of which 373 are distinct)
EPHA1
(1 mutation)
EPHA10 isoform 1
(3 mutations, of which 3 are distinct)
EPHA2
(1 mutation)
EPHA3 isoform a
(8 mutations, of which 4 are distinct)
EPHA4
(4 mutations, of which 4 are distinct)
EPHA5 isoform a
(10 mutations, of which 5 are distinct)
EPHA5 isoform b
(10 mutations, of which 5 are distinct)
EPHA7
(3 mutations, of which 3 are distinct)
EPHA8 isoform 1
(6 mutations, of which 6 are distinct)
EPHB1
(5 mutations, of which 5 are distinct)
EPHB2 isoform 1
(2 mutations, of which 1 is distinct)
EPHB2 isoform 2 EPHB3
(5 mutations, of which 4 are distinct)
EPHB4
(6 mutations, of which 5 are distinct)
EPHB6
(2 mutations, of which 2 are distinct)
ERBB2 isoform a
(81 mutations, of which 25 are distinct)
ERBB2 isoform b ERBB3 isoform 1
(2 mutations, of which 2 are distinct)
ERBB4
(5 mutations, of which 4 are distinct)
FER
(2 mutations, of which 2 are distinct)
FES FGFR1 isoform 1
(6 mutations, of which 5 are distinct)
FGFR1 isoform 2 FGFR1 isoform 3 FGFR1 isoform 4
FGFR1 isoform 9
(6 mutations, of which 5 are distinct)
FGFR2 isoform 1
(9 mutations, of which 6 are distinct)
FGFR2 isoform 2
(9 mutations, of which 6 are distinct)
FGFR3 isoform 1
(513 mutations, of which 16 are distinct)
FGFR4 isoform 1.1
FGFR4 isoform 1.2 FGFR4 isoform 2
(5 mutations, of which 4 are distinct)
FGR
(1 mutation)
FLT1
(6 mutations, of which 5 are distinct)
FLT3
(333 mutations, of which 41 are distinct)
FLT4 isoform 1
(3 mutations, of which 3 are distinct)
FLT4 isoform 2
(3 mutations, of which 3 are distinct)
FRK
(2 mutations, of which 1 is distinct)
FYN isoform a
(3 mutations, of which 3 are distinct)
FYN isoform b
FYN isoform c GUCY2C
(1 mutation)
GUCY2D
(1 mutation)
GUCY2F
(8 mutations, of which 5 are distinct)
HCK isoform p61HCK
IGF1R
(6 mutations, of which 5 are distinct)
ILK isoform a.1 ILK isoform a.2 ILK isoform a.3 INSR
(3 mutations, of which 3 are distinct)
INSRR
(4 mutations, of which 3 are distinct)
ITK
(3 mutations, of which 3 are distinct)
JAK1
(1 mutation)
JAK2
(3034 mutations, of which 9 are distinct)
JAK3
(1 mutation)
KDR
(3 mutations, of which 2 are distinct)
KIAA1804 KIT
(3493 mutations, of which 102 are distinct)
KSR1 LCK
(1 mutation)
LIMK1 isoform 1
(1 mutation)
LIMK2 isoform 2a LIMK2 isoform 2b LMTK2
(2 mutations, of which 2 are distinct)
LTK isoform 1
LTK isoform 2
(1 mutation)
LYN
(1 mutation)
MAP3K10
(1 mutation)
MAP3K11 MAP3K12
(1 mutation)
MAP3K13
(1 mutation)
MAP3K9
(2 mutations, of which 2 are distinct)
MATK isoform a
(2 mutations, of which 2 are distinct)
MATK isoform b MATK isoform c
(2 mutations, of which 2 are distinct)
MERTK
(2 mutations, of which 2 are distinct)
MET
(114 mutations, of which 68 are distinct)
MST1R
(1 mutation)
MUSK
(2 mutations, of which 1 is distinct)
NPR1
(2 mutations, of which 2 are distinct)
NPR2 NTRK1 isoform 1 NTRK1 isoform 2
(4 mutations, of which 3 are distinct)
NTRK1 isoform 3 NTRK2 isoform a
(5 mutations, of which 3 are distinct)
NTRK2 isoform c NTRK3 isoform a
(9 mutations, of which 7 are distinct)
NTRK3 isoform b
(9 mutations, of which 7 are distinct)
PDGFRA
(522 mutations, of which 33 are distinct)
PDGFRB
(3 mutations, of which 3 are distinct)
PTK2B isoform a.1
(1 mutation)
PTK2B isoform a.2
(1 mutation)
PTK2B isoform a.3
(1 mutation)
PTK2B isoform b
(1 mutation)
PTK2 isoform a
PTK2 isoform b
(2 mutations, of which 2 are distinct)
PTK6 PTK7 isoform a
(1 mutation)
PTK7 isoform b PTK7 isoform c
PTK7 isoform d RET isoform a
(335 mutations, of which 61 are distinct)
RET isoform c
(335 mutations, of which 61 are distinct)
RIPK2 ROR1
(7 mutations, of which 7 are distinct)
ROR2
(3 mutations, of which 3 are distinct)
ROS1
(5 mutations, of which 4 are distinct)
RYK isoform 1 RYK isoform 2 SRC isoform a.1
(10 mutations, of which 1 is distinct)
SRC isoform a.2
(10 mutations, of which 1 is distinct)
SRMS STYK1
(1 mutation)
SYK TEC
(3 mutations, of which 2 are distinct)
TEK
(4 mutations, of which 4 are distinct)
TEX14 isoform a
(9 mutations, of which 8 are distinct)
TEX14 isoform b
(9 mutations, of which 8 are distinct)
TIE1 TNK1
(2 mutations, of which 1 is distinct)
TNK2 isoform 1 TNK2 isoform 2 TNNI3K TXK TYK2
(2 mutations, of which 2 are distinct)
TYRO3 YES1 ZAK isoform 1
(1 mutation)
ZAK isoform 2
(1 mutation)
ZAP70 isoform 1
(2 mutations, of which 2 are distinct)
ZAP70 isoform 2