Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

The Sarcoma Genome Project is a collaboration between Memorial Sloan-Kettering Cancer Center and The Broad Institute.

Nature Genetics. 2010 July 4. [Abstract] [Full Text] [PDF] [Data via GEO] [Data Portal]

Highlights:

  • Integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes
  • Detailed map of molecular alterations across diverse sarcoma subtypes
  • PIK3CA is mutated in 18% of myxoid and round-cell liposarcomas and associated with Akt activation and poor clinical outcome
  • NF1 is mutated and deleted in myxofibrosarcomas and pleomorphic liposarcomas
  • shRNA knockdown of genes amplified in dedifferentiated liposarcoma idenifies genes involved in cell proliferation

Visit the Data Portal to explore the data.