CancerGenomics

Pathway analysis of genetic alterations in glioblastoma (TCGA)

Mondrian, the Genome Data Mapper Software, maps genomic data onto pathways.

To map genomic data from the glioblastoma project onto a pathway of genes frequently altered in glioblastoma, use one of the buttons below:

Using information from the literature and public pathway databases, we have assembled a pathway representation of the most frequently altered genes in glioblastoma. This pathway is available as a Cytoscape session file or as a PDF document.

In collaboration with Lawrence Donehower, David Wheeler and Beatriz Santillan at Baylor College of Medicine, we have analyzed alterations of individual sub-pathways using copy-number alterations and mutations in 601 genes. Results from this analysis are part of the TCGA consortium paper, and can also be viewed here:

- Copy-number alterations and mutations of pathway genes (91 samples)
       - per sample spreadsheet (PDF)
       - overall percentages mapped onto the GBM pathway (PDF)

- Copy-number alterations mapped on the GBM pathway (206 samples)
       - per sample spreadsheet (PDF)
       - overall percentages mapped onto the GBM pathway (PDF)