Somatic mutations in glioblastoma (TCGA)

The following table represents mutations found in 91 glioblastoma samples. The analysis is based on 601 sequenced genes, and only genes with two or more missense mutations are shown.

Genes in the table are hyperlinked to more detailed mutation information from the cBio Cancer Genomics Portal, which also shows the predicted functional impact of missense mutations (computed by Mutation Assessor).
Genesamplesmutationsmissensenonsenseframshiftindelinsertsplicesite
TP53 31383124  1
PTEN 283012612   
NF1 1319564  4
EGFR 151616     
ERBB2 101110    1
PIK3R1 993 6   
PIK3CA 664 2   
COL1A1 243    1
FN1 344     
MSH6 444     
EP300 333     
FURIN 233     
ITGB3 333     
MLH1 233     
TNC 333     
TSC2 233     
A2M 222     
ABCC4 222     
ASPM 122     
BCAR1 222     
AGAP2 (CENTG1) 222     
CHAT 222     
CYP27B1 222     
EPHA7 222     
GATA3 222     
HSP90AA1 222     
IRS1 222     
LDHA 222     
MAPK9 222     
MSH2 222     
MSI1 222     
NMBR 222     
NOS3 122     
PDGFRB 222     
PI15 222     
PRKCZ 222     
PTPN11 222     
ROR2 222     
TAF1 222     
TERT 222     
TRIM3 222     
ZNF384 122     

Data Portal

Explore cancer genomics data via the cBio Cancer Genomics Portal.

News

The CGDS R-package has been released.

NetBox version 1 has been released.

The Cancer Genome Atlas has announced the selection of six Genome Data Analysis Centers.

Publications

Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2011 Sep 9. [Abstract] [PDF]

Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29. [Abstract] [Full Text] [PDF]

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res.. 2011 Jan (Database issue). [Abstract] [Full Text] [PDF]

Gene Ranker

Explore cancer genes with Gene Ranker.