Integrated analysis of genetic alterations in a large set of glioblastoma samples from The Cancer Genome Atlas (TCGA) project

The Cancer Genome Atlas Project is an NIH-sponsored program to systematically catalog the genetic alterations in human cancers. The first cancer type investigated is Glioblastoma multiforme (GBM), the most common and most aggressive form of brain cancer.

This site presents the results of detailed analysis and access to analysis tools in the areas of signaling pathways, mutations, and copy number alterations.

Some of these results are reported in the first TCGA publication: Comprehensive genomic characterization defines human glioblastoma genes and core pathways. (4 September 2008, Nature) The Cancer Genome Atlas Research Network. [Abstract] [PDF] [Supplementary information]

 

Signaling Pathways

Mutations

DNA Copy Number

Data Portal

Access TCGA genomic data via our Data Portal.

Gene Ranker

Explore TCGA Phase III sequencing genes with Gene Ranker.

News

The Cancer Genome Atlas Reports First Results Of Comprehensive Study of Brain Tumors (4 September 2008, NIH Press Release)

Cancer complexity slows quest for cure (4 September 2008, Nature)

An Integrated Genomic Analysis of Human Glioblastoma Multiforme. D. Williams Parsons, et. al. (4 September, Science)

Publications

Comprehensive genomic characterization defines human glioblastoma genes and core pathways. The Cancer Genome Atlas Research Network. (4 September 2008, Nature) [Abstract] [PDF] [Supplementary information]

CancerGenes: a gene selection resource for cancer genome projects. Higgins ME, et. al. Nucleic Acids Res. 2007 Jan (Database issue:D721-6. [PubMed Abstract] [Full Text] [PDF]