Step 1: Select Cancer Type:   Glioblastoma multiforme (GBM)

Step 2: Select Genetic Profile:

Copy number alterations, GBM Pathways: Copy number alteration data for all genes in the hand-curated pathway of genes implicated in glioblastoma (206 cases). These calls were used for the pathway analysis in the initial TCGA manuscript, and they are the consensus of a combination of different platforms (Agilent, Affymetrix SNP6, Illumina) and methods (RAE, GISTIC, GTS). Values: -2 = homozygous deletion; -1 = hemizygous deletion; 0 = neutral / no change; 1 = gain; 2 = high level amplification.

Copy number alterations (RAE algorithm): Copy number alteration data for 17,789 genes in 203 GBM cases. Copy number calls were determined using the RAE algorithm by Barry Taylor @ MSKCC. Values: -2 = homozygous deletion; -1 = hemizygous deletion; 0 = neutral / no change; 1 = gain; 2 = high level amplification.

mRNA Expression: mRNA expression levels for 17,789 genes in 206 GBM cases using integrated values from the Affymetrix U133, Affymetrix Exon, and Agilent Platforms.

Mutations: Mutation data for 601 sequenced genes (Phase I of the TCGA glioblastoma project).

Step 3: Select Case Set:  

GBM 206 GBM 91 GBM All Custom List

Clicking on any of the links below will download a tab-delimited clinical data file.

• GBM 206: 206 cases with copy number data, as used in the TCGA glioblastoma manuscript.
• GBM 91: 91 cases with Phase I sequencing and copy number data, as used in the TCGA glioblastoma manuscript.
• GBM All: All cases as used in the TCGA glioblastoma manuscript.

Step 4: Enter Gene Set:   Custom TP53 Pathway RTK/Ras/PI3K/AKT Signaling RB Pathway

 Enter / edit gene symbols below:

Clicking submit will generate a tab-delimited file containing your requested data.

Transpose data matrix.