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Protein 3D Structure Computed from Evolutionary Sequence Variation. PLoS ONE. 2011 Dec 7.
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RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol. 2011 Nov 13.
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Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29.
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Computational biology research at Memorial Sloan-Kettering Cancer Center (MSKCC) pursues computational biology research projects and the development of bioinformatics resources in the areas of
- sequence-structure analysis
- gene regulation
- molecular pathways and networks
- diagnostic and prognostic indicators
The mission of cBio is to move the theoretical methods and genome-scale data resources of computational biology into everyday laboratory practice and use, and is reflected in the organization of cBio into research and service components ~ the intention being that new computational methods created through the process of scientific inquiry should be generalized and supported as open-source and shared community resources.
cBio is organized into closely knit research and service components. There are currently four research groups -- headed by Chris Sander, Gregoire Altan-Bonnet, Christina Leslie and Joao Xavier. The Bioinformatics Core is responsible for providing various computational and bioinformatics services to MSKCC and the Tri-Institutions of the Upper East Side of Manhattan.
In 2002, MSKCC made a major commitment to infrastructure investment and translational cancer research by creating cBio. cBio consists of a vibrant work environment with both research and service components, and provides a number of opportunities to contribute to the fields of computational biology and bioinformatics, as well as to basic and clinical research studies at one of the world's premier cancer research institutes.
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